Matrix alkalinization: a novel mitochondrial signal for sustained pancreatic β-cell activation
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چکیده
منابع مشابه
Matrix alkalinization: a novel mitochondrial signal for sustained pancreatic beta-cell activation.
Nutrient secretagogues activate mitochondria of the pancreatic beta-cell through the provision of substrate, hyperpolarisation of the inner mitochondrial membrane and mitochondrial calcium rises. We report that mitochondrial matrix pH, a parameter not previously studied in the beta-cell, also exerts an important control function in mitochondrial metabolism. During nutrient stimulation matrix pH...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2009
ISSN: 0261-4189,1460-2075
DOI: 10.1038/emboj.2008.302